1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain

  • J Nat Prod. 2015 Feb 27;78(2):301-5. doi: 10.1021/np500468f.
Peng Sun  1 ,  Qunfei Zhao ,  Zhuhua Wu ,  Wen Zhang ,  Wen Liu
Affiliations
  • 1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University , 325 Guo-He Road, Shanghai 200433, People's Republic of China.
PMID: 25611131 DOI: 10.1021/np500468f
Abstract

Three new 1,19-seco-avermectin (AVE) analogues were isolated from the ΔaveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed spectroscopic analysis. This is the first report of 1,19-seco-AVE analogues. In an in vitro assay these compounds displayed cytotoxicity against Saos-2, MG-63, and B16 cell lines.