Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica

  • Bioorg Med Chem Lett. 2015 Mar 1;25(5):1129-34. doi: 10.1016/j.bmcl.2014.12.055.
To Dao Cuong  1 ,  Tran Manh Hung  1 ,  Joo-Sang Lee  1 ,  Kwon-Yeon Weon  1 ,  Mi Hee Woo  1 ,  Byung Sun Min  2
Affiliations
  • 1. College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
  • 2. College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea. Electronic address: [email protected].
PMID: 25637363 DOI: 10.1016/j.bmcl.2014.12.055
Abstract

Six new phenolics, scutellariosides A-F (1-3, 5-6, and 8), together with six known compounds (4, 7, 9-12) were isolated from the whole plant of Scutellaria indica (Labiatae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR. Their anti-inflammatory activities were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Among them, compounds 10-12 had inhibitory effects with IC50 values ranging from 7.2 to 27.8μM. Compound 12 reduced LPS-induced iNOS expression in a dose-dependent manner.

Keywords
Anti-inflammatory activity; Flavonoid; Labiatae; RAW 264.7 cells; Scutellaria indica.
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