Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

  • Bioorg Med Chem Lett. 2015 Mar 15;25(6):1192-5. doi: 10.1016/j.bmcl.2015.01.065.
Julia Heimberger  1 ,  Hannah C Cade  1 ,  Jihan Padgett  2 ,  Vinoth Sittaramane  2 ,  Abid Shaikh  3
Affiliations
  • 1. Department of Chemistry, Georgia Southern University, 521 College of Education Drive, Statesboro, GA 30460-8064, USA.
  • 2. Department of Biology, Georgia Southern University, 1332 Southern Drive, Statesboro, GA 30460-8042, USA.
  • 3. Department of Chemistry, Georgia Southern University, 521 College of Education Drive, Statesboro, GA 30460-8064, USA. Electronic address: [email protected].
PMID: 25690788 DOI: 10.1016/j.bmcl.2015.01.065
Abstract

Herbarin A and B were isolated from the Fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.

Keywords
Antioxidant properties; Natural products; Total synthesis; Toxicity; Zebrafish.
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