Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy

  • Sci Rep. 2015 Jun 22;5:11062. doi: 10.1038/srep11062.
Min Luo  1 ,  Bin Shao  1 ,  Wen Nie  2 ,  Xia-Wei Wei  1 ,  Yu-Li Li  1 ,  Bi-Lan Wang  1 ,  Zhi-Yao He  1 ,  Xiao Liang  1 ,  Ting-Hong Ye  1 ,  Yu-Quan Wei  1
Affiliations
  • 1. State Key Laboratory of Biotherapy and Laboratory for Aging Research, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, PR China.
  • 2. Department of medical oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, PR China.
PMID: 26098663 DOI: 10.1038/srep11062
Abstract

λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research, however, how the immunomodulating activity of λ-carrageenan affects tumor microenvironment remains unknown. In this study, we found that intratumoral injection of λ-carrageenan could inhibit tumor growth in B16-F10 and 4T1 bearing mice and enhance tumor immune response by increasing the number of tumor-infiltrating M1 macrophages, DCs and more activated CD4(+)CD8(+) T lymphocytes in spleen. In addition, λ-carrageenan could enhance the secretion of IL17A in spleen and significantly increase the level of TNF-α in tumor, most of which was secreted by infiltrating macrophages. Moreover, λ-carrageenan exhibited an efficient Adjuvant effect in OVA-based preventative and therapeutic vaccine for Cancer treatment, which significantly enhanced the production of anti-OVA antibody. The toxicity analysis suggested that λ-carrageenan was with a good safety profile. Thus, λ-carrageenan might be used both as a potent antitumor agent and an efficient Adjuvant in Cancer Immunotherapy.

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