Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans
- J Nat Prod. 2015 Jul 24;78(7):1511-7. doi: 10.1021/np5009619.
Affiliations
- 1. †Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan 666303, People's Republic of China.
- 2. ‡Engineering Research Center for the Development and Application of Ethnic Medicines and TCM, School of Pharmacy, Guiyang Medical College, 9 Beijing Road, Guiyang, Guizhuo 550004, People's Republic of China.
- 3. §State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Yunnan 650201, People's Republic of China.
PMID: 26103517
DOI: 10.1021/np5009619
Abstract
Nine new Alkaloids of the koumine (1-4), humantenine (5-7), and yohimbane (8, 9) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first nor-humantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the first seco-E-ring Alkaloids, respectively, of the yohimbane type. Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4.6-9.3 μM.