Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters

  • Bioorg Med Chem Lett. 2015 Sep 1;25(17):3511-4. doi: 10.1016/j.bmcl.2015.06.086.
Michał Antoszczak  1 ,  Maria Sobusiak  1 ,  Ewa Maj  2 ,  Joanna Wietrzyk  2 ,  Adam Huczyński  3
Affiliations
  • 1. Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznań, Poland.
  • 2. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wrocław, Poland.
  • 3. Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznań, Poland. Electronic address: [email protected].
PMID: 26163197 DOI: 10.1016/j.bmcl.2015.06.086
Abstract

New Salinomycin (SAL) bioconjugates with amino acid methyl esters were obtained and their antiproliferative activity against Cancer cell lines including drug-resistant ones was studied. New compounds exhibit antiproliferative activity towards leukemia and doxorubicin-resistant colon adenocarcinoma cell line and are more effective and less toxic than the commonly currently used Anticancer drugs.

Keywords
Amino acid derivatives; Anticancer activity; Doxorubicin-resistant cells; Salinomycin bioconjugates.