RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

  • J Antibiot (Tokyo). 2016 Feb;69(2):121-3. doi: 10.1038/ja.2015.94.
Hideaki Kakeya  1  2 ,  Daisuke Kaida  3  4 ,  Hiromi Sekiya  1 ,  Koji Nagai  5 ,  Minoru Yoshida  3 ,  Hiroyuki Osada  1
Affiliations
  • 1. Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
  • 2. Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
  • 3. Chemical Genetics Laboratory, RIKEN, Saitama, Japan.
  • 4. Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.
  • 5. Fermentation Research Division, Astellas Research Technologies Co. Ltd., Ibaraki, Japan.
PMID: 26350783 DOI: 10.1038/ja.2015.94
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