Alkaloids with antioxidant activities from Aconitum handelianum

  • J Asian Nat Prod Res. 2016 Jun;18(6):603-10. doi: 10.1080/10286020.2015.1114473.
Tian-Peng Yin  1 ,  Le Cai  1 ,  Yun Xing  1 ,  Jing Yu  1 ,  Xue-Jiao Li  1 ,  Rui-Feng Mei  1 ,  Zhong-Tao Ding  1
Affiliations
  • 1. a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
PMID: 26744060 DOI: 10.1080/10286020.2015.1114473
Abstract

A new C20-diterpenoid alkaloid handelidine (1) and twenty-seven known Alkaloids (2-28) were isolated from the roots of Aconitum handelianum. Their structures were established on the basis of extensive spectroscopic analyses. The study indicated that denudatine-type C20-diterpenoid Alkaloids with vicinal-triol system and benzyltetrahydroisoquinoline Alkaloids exhibited significant antioxidant activities measured by three antioxidant test systems. The aconitine-type C19-diterpenoid Alkaloids could serve as potential secondary Antioxidants for their strong binding effects to metal ions.

Keywords
Aconitum handelianum; Ranunculaceae; antioxidant; diterpenoid alkaloid; handelidine.
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