Bioactive α-pyrone meroterpenoids from mangrove endophytic fungus Penicillium sp

  • Nat Prod Res. 2016 Dec;30(24):2805-2812. doi: 10.1080/14786419.2016.1164702.
Bo Ding  1  2 ,  Zhiyuan Wang  2 ,  Xishan Huang  1 ,  Yayue Liu  1 ,  Wenrui Chen  2 ,  Zhigang She  1
Affiliations
  • 1. a School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou , China.
  • 2. b Guangdong Inspection and Quarantine Technology Center , Guangdong Entry-Exit Inspection and Quarantine Bureau , Guangzhou , China.
PMID: 27067533 DOI: 10.1080/14786419.2016.1164702
Abstract

Five α-pyrone meroterpenoids, including one new 3-epiarigsugacin E (1) and four known compounds, arisugacin D (2), arisugacin B (3), territrem C (4) and terreulactone C (5) were obtained from the marine fungus Penicillium sp. SK5GW1L. Their structures were identified by MS and NMR experiments, and the absolute configuration of compound 1 was further confirmed by low temperature (150 K) single crystal X-ray diffraction with Cu Kα radiation. Compounds 3, 4 and 5 showed strong inhibitory activities against acetylcholinesterase (AChE) with IC50 values of 3.03, 0.23 and 0.028 μM, respectively.

Keywords
sp.; -pyrone meroterpenoids; acetylcholinesterase.
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