Hydrazide-hydrazones of 3-methoxybenzoic acid and 4-tert-butylbenzoic acid with promising antibacterial activity against Bacillus spp

  • J Enzyme Inhib Med Chem. 2016;31(sup1):62-69. doi: 10.3109/14756366.2016.1170012.
Łukasz Popiołek  1 ,  Anna Biernasiuk  2
Affiliations
  • 1. a Department of Organic Chemistry and.
  • 2. b Department of Pharmaceutical Microbiology , Faculty of Pharmacy, Medical University of Lublin , Lublin , Poland.
PMID: 27075005 DOI: 10.3109/14756366.2016.1170012
Abstract

A series of 28 hydrazide-hydrazones of 3-methoxybenzoic and 4-tert-butylbenzoic acid were synthesized and screened in vitro against the panel of reference strains of bacteria and fungi with the use of the broth microdilution method according to EUCAST and CLSI guidelines. Five of the synthesized compounds were found to exhibit high bacteriostatic or bactericidal activity against Gram-positive bacteria. The antimicrobial activity of compounds 13, 14, and 16 against Bacillus spp. was higher than that of commonly used Antibiotics, like cefuroxime or ampicillin.

Keywords
Antimicrobial activity; Bacillus spp.; MBC; MIC; hydrazide-hydrazones.
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