New isoindolinones from the fruiting bodies of Hericium erinaceum

  • Fitoterapia. 2016 Jun:111:58-65. doi: 10.1016/j.fitote.2016.04.010.
Xu-Li Wang  1 ,  Kang-Ping Xu  2 ,  Hong-Ping Long  2 ,  Hui Zou  2 ,  Xiao-Zheng Cao  2 ,  Kai Zhang  2 ,  Jian-Zhong Hu  3 ,  Shu-Jin He  4 ,  Gang-Zhi Zhu  5 ,  Xiao-Ai He  5 ,  Ping-Sheng Xu  6 ,  Gui-Shan Tan  7
Affiliations
  • 1. Xiangya Hospital, Central South University, Changsha 410008, China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
  • 2. School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
  • 3. Xiangya Hospital, Central South University, Changsha 410008, China.
  • 4. Hunan Xinhui Pharmaceutical Co., Ltd., Changsha 410200, China.
  • 5. Haikou People's Hospital, Haikou 570208, China.
  • 6. Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: [email protected].
  • 7. Xiangya Hospital, Central South University, Changsha 410008, China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Electronic address: [email protected].
PMID: 27094113 DOI: 10.1016/j.fitote.2016.04.010
Abstract

Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates. In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H. erinaceus. The structures of new compounds were validated by HRESIMS and 1D, 2D NMR. It's worth mentioning that there are two pairs of isomers included in the new compounds. Moreover, their cytotoxicity against metastatic human hepatocellular carcinoma cell lines SMMC-7221 and MHCC-97H were evaluated. The results showed that compounds 6 and 7 exhibited promising inhibitory potency against the growth of two cell lines.

Keywords
Cytotoxicity; Erinaceolactams A-E; Fruiting bodies; Hericium erinaceus; Isoindolinone.
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