Antifungal activity of the piroctone olamine in experimental intra-abdominal candidiasis

  • Springerplus. 2016 Apr 16;5:468. doi: 10.1186/s40064-016-2130-8.
Fabíola Maria Marques do Couto  1 ,  Silene Carneiro do Nascimento  2 ,  Silvio Francisco Pereira Júnior  1 ,  Vanessa Karina Alves da Silva  1 ,  André Ferraz Goiana Leal  1 ,  Rejane Pereira Neves  1
Affiliations
  • 1. Department of Mycology, Federal University of Pernambuco (UFPE), Av. da Engenharia, s/n, Cidade Universitária, Recife, PE CEP 50740-550 Brazil.
  • 2. Department of Antibiotics, Federal University of Pernambuco (UFPE), Av. da Engenharia, s/n, Cidade Universitária, Recife, PE CEP 50740-550 Brazil.
PMID: 27119072 DOI: 10.1186/s40064-016-2130-8
Abstract

This work aimed to evaluate the Antifungal activity of piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The mice (n = 6) were infected by intraperitoneal injection of 0.2 ml of C. albicans (10(7)cells/ml in saline). The Animals were observed daily for clinical signs and mortality for 14 days. The treatment with piroctone olamine (0.5 mg/kg) was performed 72 h after Infection by intraperitoneal administration. For comparison, a group of Animals (n = 6) was treated with amphotericin B (0.5 mg/kg). The mycological diagnosis was made by collecting the liver, spleen and kidneys. Data regarding the Fungal growth and mortality were analyzed statistically by Student's t test and analysis of variance (ANOVA), with level of significance set at P < 0.05. The difference in Fungal growth scoring between the control group and the treatment groups (piroctone olamine and amphotericin B) was statistically significant (P < 0.05). The difference in Fungal growth scoring between the treatment groups (piroctone olamine and amphotericin B) was not statistically significant (P < 0.05).

Keywords
Activity antifungal; Intra-abdominal candidiasis; Piroctone olamine.
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