Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity

  • J Nat Prod. 2016 Jun 24;79(6):1628-34. doi: 10.1021/acs.jnatprod.6b00206.
Luo-Sheng Wan  1 ,  Rui Chu  1  2 ,  Xing-Rong Peng  1 ,  Guo-Lei Zhu  1  2 ,  Mu-Yuan Yu  1  2 ,  Lei Li  1  2 ,  Lin Zhou  1 ,  Shuang-Yang Lu  1  2 ,  Jin-Run Dong  1  2 ,  Zhi-Run Zhang  1 ,  Yan Li  1 ,  Ming-Hua Qiu  1  2
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
  • 2. University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
PMID: 27203291 DOI: 10.1021/acs.jnatprod.6b00206
Abstract

Twelve new Diterpenoids based on two rare skeletal types, namely, paralianones A-D (1-4) and pepluanols A-H (5-12), along with five known compounds, were isolated from an acetone extract of Euphorbia peplus. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. These Diterpenoids were evaluated for potential anti-inflammatory activity in a lipopolysaccharide-stimulated mouse macrophage cellular model. Compounds 3, 4, 11, 13, and 16 displayed moderate inhibitory effects on NO inhibition, with IC50 values ranging from 29.9 to 38.3 μM.