Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

  • Bioorg Med Chem Lett. 2016 Aug 1;26(15):3780-4. doi: 10.1016/j.bmcl.2016.05.048.
Pham Hai Yen  1 ,  Vu Thi Quynh Chi  1 ,  Phan Van Kiem  2 ,  Bui Huu Tai  1 ,  Tran Hong Quang  1 ,  Nguyen Xuan Nhiem  1 ,  Hoang Le Tuan Anh  1 ,  Ninh Khac Ban  1 ,  Bui Van Thanh  3 ,  Chau Van Minh  1 ,  SeonJu Park  1 ,  Seung Hyun Kim  4
Affiliations
  • 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: [email protected].
  • 3. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 4. College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 406-840, Republic of Korea. Electronic address: [email protected].
PMID: 27287369 DOI: 10.1016/j.bmcl.2016.05.048
Abstract

Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A-E (1-5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→3)]-β-d-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosyl-(1→3)]-β-d-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3-5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC50 values ranging from 37.0 to 60.7μM.

Keywords
Anti-inflammation; Steroidal saponin; Tacca vietnamensis; Taccaceae.