Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231)

  • Steroids. 2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008.
Mahmoud Aghaei  1 ,  Zeinab Yazdiniapour  2 ,  Mustafa Ghanadian  3 ,  Behzad Zolfaghari  2 ,  Virginia Lanzotti  4 ,  Vahid Mirsafaee  2
Affiliations
  • 1. Department of Biochemistry, Isfahan University of Medical Sciences, Isfahan, Iran.
  • 2. Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
  • 3. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: [email protected].
  • 4. Dipartimento di Agraria, Università di Napoli Federico II, Portici, Napoli, Italy. Electronic address: [email protected].
PMID: 27474490 DOI: 10.1016/j.steroids.2016.07.008
Abstract

From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related Steroids (2-3) have been isolated and characterized along with a known cycloartane derivative (4). The chemical structure of the obtusifoliol-related compounds, obtained by 1D and 2D NMR, and MS measurements, have been determined as: 3β,7α-dihydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-11-one (2) and 3β-hydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-1-one (3). Compound 2 has been previously isolated from Euphorbia chamaesyce while compound 3 was never reported before. The isolated compounds 1-4 were subjected to cytotoxic tests on the breast Cancer cells, MCF-7 and MDA-MB231. Further pharmacological tests on the more active compounds 2 and 3 indicated their action to be related to cell growth inhibitory activity and apoptotic effects on the tested cells.

Keywords
4α-Methyl sterols; Anticancer; Apoptosis; Breast cancer; Euphorbia sogdiana; Obtusifoliol analogues.
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