New labdane diterpenoids from Croton laui and their anti-inflammatory activities

  • Bioorg Med Chem Lett. 2016 Oct 1;26(19):4687-4691. doi: 10.1016/j.bmcl.2016.08.052.
Li Yang  1 ,  Yu-Bo Zhang  1 ,  Li-Feng Chen  1 ,  Neng-Hua Chen  1 ,  Zhong-Nan Wu  1 ,  Si-Qi Jiang  1 ,  Lin Jiang  1 ,  Guo-Qiang Li  1 ,  Yao-Lan Li  2 ,  Guo-Cai Wang  3
Affiliations
  • 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
  • 2. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: [email protected].
  • 3. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: [email protected].
PMID: 27575472 DOI: 10.1016/j.bmcl.2016.08.052
Abstract

Nine new labdane Diterpenoids (1-9) were isolated from the aerial parts of Croton laui, along with eight known analogues (10-17). Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, 1D and 2D NMR), and the structure of 8 was confirmed by single crystal X-ray diffraction analyses. In addition, compounds 1, 4, 7, 8, and 14 showed weak anti-inflammatory activities in LPS-stimulated RAW 264.7 cells.

Keywords
Anti-inflammatory activity; Croton laui; Labdane diterpenoid.