Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae)

  • Bioorg Med Chem Lett. 2016 Dec 1;26(23):5773-5779. doi: 10.1016/j.bmcl.2016.10.045.
Sakchai Hongthong  1 ,  Jatuporn Meesin  1 ,  Phanruethai Pailee  2 ,  Darunee Soorukram  1 ,  Palangpon Kongsaeree  1 ,  Samran Prabpai  1 ,  Pawinee Piyachaturawat  3 ,  Surawat Jariyawat  3 ,  Kanoknetr Suksen  3 ,  Thaworn Jaipetch  4 ,  Narong Nuntasaen  5 ,  Vichai Reutrakul  1 ,  Chutima Kuhakarn  6
Affiliations
  • 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • 2. Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
  • 3. Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • 4. Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand.
  • 5. The Forest Herbarium National Park, Wildlife and Plant Conservation Department, Ministry of Natural Resources and Environment, Bangkok, Thailand.
  • 6. Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. Electronic address: [email protected].
PMID: 27793565 DOI: 10.1016/j.bmcl.2016.10.045
Abstract

Five new lanostanes, wallichinanes A-E (1-5) together with a known lanostane derivative 6 were isolated from the cytotoxic hexanes extract of fruits of Garcinia wallichii Choisy (Guttiferae). The structures of the isolated compounds were established by analysis of spectroscopic data, X-ray diffraction technique as well as comparison with the literature data. The cytotoxicity of all isolated compounds against a panel of cultured Cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED50 values ranging from 3.91 to 7.63μM.

Keywords
Cytotoxicity; Garcinia wallichii; Guttiferae; Lanostane; Triterpene.