The anxiolitic effects of BTG1640 and BTG1675A on ultrasonic isolation calls and locomotor activity of rat pups

  • Eur Rev Med Pharmacol Sci. 2016 Dec;20(23):4980-4984.
M Niculescu  1 ,  R Cagiano ,  M Caprio ,  S Damian ,  E Boia ,  D Vermesan ,  M Tattoli ,  H Haragus
Affiliations
  • 1. Faculty of Medicine, University "Titu Maiorescu", Bucharest, Romania. [email protected].
PMID: 27981534
Abstract

Objective: The aim of the present study was to evaluate the anxiolytic properties of the new isoxazoline compounds BTG1640 and BTG1675A in comparison with diazepam.

Materials and methods: We evaluated the ultrasonic distress emission in both sexes of neonatal rat pups (which seems to be a sensitive indicator of the rat emotional reactivity and represents a valuable tool to screen compounds with expected anxiolytic properties) and the locomotor activity in 30-day old rat pups.

Results: We found a significant reduction in the number of emitted ultrasonic calls only after i.p. administration of diazepam 1 mg/kg, while no significant reduction have been detected after i.p. administration of BTG 1640 and BTG 1675A. Furthermore, we found a significant reduction of locomotor activity in the first 10' of the test, only in the group treated with diazepam 0.1 mg.

Conclusions: The tests validating the supposed anxiolytic properties of the new isoxazoline compounds BTG1640 and BTG1675A, in comparison with diazepam, gave negative results.

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