Commiphoranes A-D, Carbon Skeletal Terpenoids from Resina Commiphora

  • Org Lett. 2017 Jan 6;19(1):286-289. doi: 10.1021/acs.orglett.6b03661.
Lu Dong  1  2 ,  Li-Zhi Cheng  1  2 ,  Yong-Ming Yan  1 ,  Shu-Mei Wang  2 ,  Yong-Xian Cheng  1
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, PR China.
  • 2. Guangdong Pharmaceutical University , Guangzhou 510006, PR China.
PMID: 28029263 DOI: 10.1021/acs.orglett.6b03661
Abstract

Commiphoranes A-D (1-4), four novel aromatic Terpenoids with unprecedented carbon skeletons, were isolated from Resina Commiphora. Their structures were identified by spectroscopic and crystallographic methods. Compounds 1 and 2 are dinorditerpenoids characteristic of a 6/6/6/6 ring system. In contrast, compounds 3 and 4 are sesquiterpenoids possessing a 5/6/7 backbone. Biological evaluation reveals that 3 could significantly attenuate overproduction of fibronectin, Collagen I, and α-SMA in TGF-β1-induced rat renal proximal tubular cells.

Products