A new dimeric stilbene from the lianas of Gnetum parvifolium

  • Nat Prod Res. 2017 Jul;31(13):1495-1500. doi: 10.1080/14786419.2017.1278591.
Li-Wen Tian  1 ,  Jun-Jiang Lv  2 ,  Yao Liu  1 ,  Lu-Yao Song  3 ,  Lian-Bing Hou  3 ,  Cheng Zhong  1 ,  Yang Xie  1
Affiliations
  • 1. a School of Pharmaceutical Sciences , Southern Medical University , Guangzhou , People's Republic of China.
  • 2. b Chemistry and Chemical Engineering college , Chongqing University , Chongqing , People's Republic of China.
  • 3. c Department of Pharmacy, Nangfang Hospital , Southern Medical University , Guangzhou , People's Republic of China.
PMID: 28081652 DOI: 10.1080/14786419.2017.1278591
Abstract

A new dimeric stilbene, gnetifolin P (1), was isolated from the lianas of Gnetum parvifolium, together with seven known compounds 2-8. The structure of compound 1 was determined by extensive NMR and HRESIMS data analyses, and quantum chemical calculations. All the compounds were evaluated for their anti-inflammatory activity. Compounds 1 and 6 inhibited the expression of IL-1β on LPS induced THP-1 cells with the inhibition rate of 35.78 and 64.67%, respectively, at concentration of 25 μg/mL.

Keywords
ECD calculation; Gnetum parvifolium; anti-inflammatory activity; dimeric stilbene.
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