Four New Nanaomycins Produced by Streptomyces hebeiensis Derived from Lichen

  • Chem Biodivers. 2017 Jul;14(7). doi: 10.1002/cbdv.201700057.
Chengbin Liu  1 ,  Yi Jiang  2 ,  Hui Lei  1 ,  Xiu Chen  1 ,  Qingjuan Ma  1 ,  Li Han  1 ,  Xueshi Huang  1
Affiliations
  • 1. Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
  • 2. Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, P. R. China.
PMID: 28390085 DOI: 10.1002/cbdv.201700057
Abstract

Four new nanaomycins (1 - 4), together with two known compounds, nanaomycin αA (5) and nanaomycin βA (6) were isolated from a fermentation broth of Streptomyces hebeiensis derived from Lichen. The structures of the new nanaomycins 1 - 4 were established using comprehensive NMR spectroscopic data analysis as well as UV, IR, and MS data. The antimicrobial activities of 1 - 6 were evaluated against Gram-positive bacteria and fungus. Compounds 5 and 6 showed antimicrobial activities against the test Microorganisms, while 1 - 4 were inactive at 100 μg/ml.

Keywords
Streptomyces hebeiensis; Antimicrobial activity; Lichen; Nanaomycin.
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