Gunnilactams A-C, Macrocyclic Tetralactams from the Mycelial Culture of the Entomogenous Fungus Paecilomyces gunnii

  • J Nat Prod. 2017 Jun 23;80(6):1935-1938. doi: 10.1021/acs.jnatprod.7b00060.
Yongbiao Zheng  1 ,  Jiyan Zhang  1 ,  Liufeng Wei  1 ,  Mianmian Shi  1 ,  Jifeng Wang  2 ,  Jianzhong Huang  1
Affiliations
  • 1. Engineering Research Center of Industrial Microbiology, College of Life Sciences, Fujian Normal University , Fuzhou 350117, People's Republic of China.
  • 2. Fudan Institute of Urology, the Fifth People's Hospital of Shanghai, Fudan University , Shanghai 200240, People's Republic of China.
PMID: 28562046 DOI: 10.1021/acs.jnatprod.7b00060
Abstract

Three novel macrocyclic tetralactams, gunnilactam A (1), gunnilactam B (2), and gunnilactam C (3), were isolated from the submerged fermentation broth of Paecilomyces gunnii, an entomogenous fungus identified as the anamorph of Cordyceps gunnii. Their structures were determined using NMR data, HREIMS, and single-crystal X-ray crystallography. Gunnilactam A exhibited selective cytotoxic activity against human prostate Cancer C42B cells with an IC50 value of 5.4 μM.

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