New Prenylated ortho-Dihydroxycoumarins from the Fruits of Ficus nipponica

  • Chem Biodivers. 2017 Sep;14(9). doi: 10.1002/cbdv.201700196.
Yui Akihara  1 ,  Emi Ohta  1 ,  Tatsuo Nehira  2 ,  Hisashi Ômura  1 ,  Shinji Ohta  1
Affiliations
  • 1. Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
  • 2. Graduate School of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
PMID: 28574644 DOI: 10.1002/cbdv.201700196
Abstract

Two new prenylated ortho-dihydroxycoumarins, designated fipsomin (1) and fipsotwin (2), were isolated from the fruits of Ficus nipponica together with a known prenylated coumarin, apigravin (3). Their structures were established by spectroscopic data and X-ray crystallographic analysis. Compound 1 exhibited Antibacterial activity against Bacillus subtilis with an MIC value of 61 μm, while 2 and 3 showed very weak activity.

Keywords
Ficus nipponica; Fipsomin; Fipsotwin; Moraceae; Prenylated coumarin.
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