Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells

  • Phytochemistry. 2018 Jan:145:10-17. doi: 10.1016/j.phytochem.2017.09.020.
Xin-Yi Liu  1 ,  Shan Wang  1 ,  Chuang-Jun Li  1 ,  Jie Ma  1 ,  Fang-You Chen  1 ,  Ying Peng  1 ,  Xiao-Liang Wang  1 ,  Dong-Ming Zhang  2
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: [email protected].
PMID: 29035776 DOI: 10.1016/j.phytochem.2017.09.020
Abstract

Seven dammarane-type saponins previously undescribed (notoginsenosides Fh1-Fh7) were isolated from the aqueous extract leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eleven known saponins. Their structures of were elucidated by spectroscopic analysis (NMR, UV, IR, ect.), HR-ESI-MS techniques and chemical methods. Screening results indicated that compounds 4, 5, 12, 13 showed moderate neuroprotective effects on H2O2-induced cellular damage in human neuroblastoma SH-SY5Y cells (10 μM).

Keywords
Araliaceae; Neuroprotective; Panax notoginseng; Saponins.
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