A new polyketide purpurogenic acid: the activated production of polyketides by the diethyl sulphate mutagenesis of marine-derived Penicillium purpurogenum G59

  • Nat Prod Res. 2019 Jan;33(1):89-94. doi: 10.1080/14786419.2018.1434644.
Ming-Wen Xia  1 ,  Yu Yang  1 ,  Rui Xu  1 ,  Chang-Wei Li  1 ,  Cheng-Bin Cui  1
Affiliations
  • 1. a State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
PMID: 29397772 DOI: 10.1080/14786419.2018.1434644
Abstract

A new polyketide, purpurogenic acid (1), and two known polyketides, (-)-mitorubrin (2) and (-)-mitorubrinol (3), were isolated from a Fungal mutant derived from the diethyl sulphate (DES) mutagenesis of marine-derived Penicillium purpurogenum G59. The planar structure of new 1 was elucidated by spectroscopic methods and the absolute configuration was assigned on the basis of [α]D and CD data. In our preliminary MTT assay, 1 inhibited human Cancer K562, HL-60, HeLa and BGC-823 cells with the inhibition rates of 52.7, 78.8, 38.4 and 35.3% at the 100 μg/mL, respectively.

Keywords
(-)-mutorubrin; (-)-mutorubrinol; Purpurogenic acid; diethyl sulphate (DES) mutagenesis; polyketides.
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