Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099

  • Leukemia. 2018 May;32(5):1246-1249. doi: 10.1038/s41375-018-0020-5.
X Sun  1 ,  Y Ren  2 ,  S Gunawan  3 ,  P Teng  4 ,  Z Chen  2 ,  H R Lawrence  3 ,  J Cai  4 ,  N J Lawrence  3 ,  J Wu  5  6  7
Affiliations
  • 1. Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • 2. Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • 3. Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • 4. Department of Chemistry, University of South Florida, Tampa, FL, USA.
  • 5. Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].
  • 6. Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. [email protected].
  • 7. Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].
PMID: 29568093 DOI: 10.1038/s41375-018-0020-5
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