Structures and Biological Evaluation of Monoterpenoid Glycosides from the Roots of Paeonia lactiflora

  • J Nat Prod. 2018 May 25;81(5):1252-1259. doi: 10.1021/acs.jnatprod.8b00087.
Rui Li  1 ,  Jing-Fang Zhang  1 ,  Yu-Zhuo Wu  1 ,  Yan-Cheng Li  1 ,  Gui-Yang Xia  1 ,  Ling-Yan Wang  1 ,  Bo-Lin Qiu  1 ,  Min Ma  1 ,  Sheng Lin  1
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
PMID: 29741372 DOI: 10.1021/acs.jnatprod.8b00087
Abstract

Fractionation of an aqueous extract of the air-dried roots of a traditional Chinese medicinal plant, Paeonia lactiflora, yielded the new monoterpenoid glycosides 1-10. Their structures were assigned via spectroscopic techniques, and the absolute configurations of 1, 4-6, and 8 were verified via chemical methods, specific rotation, and electronic circular dichroism data. Compounds 1-4 are rare compared to the reported cage-like paeoniflorin derivatives; that is, they comprised two monoterpenoidal moieties. In the in vitro assay, compounds 5, 8, and 9 showed weak inhibitions against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, with IC50 values of 64.8, 60.1, and 97.5 μM, respectively.