Whirling Platelets Away for Transfusion

  • Cell. 2018 Jul 26;174(3):503-504. doi: 10.1016/j.cell.2018.07.018.
Camelia Iancu-Rubin  1 ,  Ronald Hoffman  1 ,  Anna Rita Migliaccio  2
Affiliations
  • 1. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
  • 2. Department of Biomedical and Neuromotorial Sciences, Alma Mater University, Bologna, Italy. Electronic address: [email protected].
PMID: 30053423 DOI: 10.1016/j.cell.2018.07.018
Abstract

With a growing demand for platelet transfusions, large-scale ex vivo platelet production would alleviate the reliance on donors. Now, Ito et al. report that turbulence is an important physical regulator of platelet generation in vivo and can be exploited in a bioreactor to enable clinical scale production of functional platelets starting from human iPSCs.