New phenoxazinone-related alkaloids from strain Streptomyces sp. KIB-H1318

  • J Antibiot (Tokyo). 2018 Nov;71(12):1040-1043. doi: 10.1038/s41429-018-0099-y.
Feng-Xian Yang  1  2 ,  Guan-Xiong Hou  1 ,  Jianying Luo  1 ,  Jing Yang  1 ,  Yijun Yan  1 ,  Sheng-Xiong Huang  3
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, 650204, Kunming, China.
  • 2. University of the Chinese Academy of Sciences, 100049, Beijing, China.
  • 3. State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, 650204, Kunming, China. [email protected].
PMID: 30218038 DOI: 10.1038/s41429-018-0099-y
Abstract

Chemical investigation of a strain Streptomyces sp. KIB-H1318 isolated from soil sample led to the discovery of three new phenoxazinone-related Alkaloids 1-3, as well as two known analogs exfoliazone (4) and viridobrunnine A (5). Their structures were determined on the basis of extensive spectroscopic analysis. The antimicrobial activity and cytotoxicity of the isolates were assayed. Exfoliazone and viridobrunnine A exhibited minor Antibacterial activity against Escherichia coli ATCC 8099, Bacillus subtilis ATCC 6633, and Staphylococcus aureus ATCC 6538. Compound 2 exhibited low cytotoxicity against two human Cancer cell lines HeLa and SW480 with the IC50 values of 36.8 and 37.8 μM, respectively.

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