Synthesis and Characterization of Anguibactin To Reveal Its Competence To Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

  • Org Lett. 2018 Oct 19;20(20):6476-6479. doi: 10.1021/acs.orglett.8b02789.
Haeun Lee  1 ,  Woon Young Song  1 ,  Minju Kim  1  2 ,  Min Wook Lee  1 ,  Soojeung Kim  1 ,  Ye Song Park  1 ,  Kyungwon Kwak  1  2 ,  Man Hwan Oh  3 ,  Hak Joong Kim  1
Affiliations
  • 1. Department of Chemistry , Korea University , 145 Anam-ro, Seongbuk-gu , Seoul 02841 , Republic of Korea.
  • 2. Center for Molecular Spectroscopy and Dynamics , Institute for Basic Science (IBS), Korea University , Seoul 02841 , Republic of Korea.
  • 3. Department of Nanobiomedical Science , Dankook University , Cheonan 31116 , Republic of Korea.
PMID: 30295497 DOI: 10.1021/acs.orglett.8b02789
Abstract

Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based Antibiotic delivery system against A. baumannii.

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