Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis
- J Nat Prod. 2018 Nov 26;81(11):2531-2538. doi: 10.1021/acs.jnatprod.8b00638.
Affiliations
- 1. High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science , Chinese Academy of Sciences , Hefei 230031 , People's Republic of China.
- 2. Institutes of Chronic Disease , Qingdao University , Qingdao 266003 , People's Republic of China.
- 3. Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy , University of Hawai'i at Hilo , Hilo , Hawaii 96720 , United States.
- 4. Institute of Physical Science and Information Technology , Anhui University , Hefei 230601 , People's Republic of China.
PMID: 30370766
DOI: 10.1021/acs.jnatprod.8b00638
Abstract
Six new phenolic acid derivatives, salviachinensines A-F (1-6), together with 14 known compounds (7-20) were isolated from the Chinese medicinal plant Salvia chinensis. The structures of salviachinensines A-F (1-6) were elucidated by NMR spectroscopy, bioinspired chemical synthesis, ECD analysis, and quantum chemical calculation methods. Compounds 2 and 3 are a pair of cis- trans isomers, and compounds 5 and 6 a pair of epimers. The solvent-induced isomerization of compounds 5 and 6 and the hypothetical biogenetic pathway of compounds 1-6, as well as the antiproliferative property and the ability of 1 to induce Apoptosis and arrest cell cycle progression of MOLM-13 cells, were also investigated.