Synthesis and biological evaluation of clovamide analogues with catechol functionality as potent Parkinson's disease agents in vitro and in vivo

  • Bioorg Med Chem Lett. 2019 Jan 15;29(2):302-312. doi: 10.1016/j.bmcl.2018.11.030.
Jia-Hao Feng  1 ,  Xiao-Long Hu  1 ,  Xian-Yu Lv  1 ,  Bao-Lin Wang  1 ,  Jun Lin  1 ,  Xiao-Qi Zhang  2 ,  Wen-Cai Ye  2 ,  Fei Xiong  3 ,  Hao Wang  4
Affiliations
  • 1. State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
  • 2. Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
  • 3. State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, People's Republic of China. Electronic address: [email protected].
  • 4. State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China. Electronic address: [email protected].
PMID: 30470490 DOI: 10.1016/j.bmcl.2018.11.030
Keywords
Catechol functionality; Clovamide analogue; Heme oxygenase-1; Oxidative stress; Parkinson’s disease; Pharmacokinetic assessment.