A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength

  • Chem Commun (Camb). 2019 Jan 29;55(10):1502-1505. doi: 10.1039/c8cc08879a.
Liangwei Zhang  1 ,  Shoujiao Peng ,  Jinyu Sun ,  Ruijuan Liu ,  Shudi Liu ,  Jianguo Fang
Affiliations
  • 1. State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. [email protected].
PMID: 30648177 DOI: 10.1039/c8cc08879a
Abstract

A ratiometric fluorescent probe of methionine sulfoxide reductase, Msr-Ratio, was disclosed for monitoring the enzyme activity in vitro and in live cells. The probe displayed favorable properties such as a nearly 400-fold fluorescence change, fast response rate (<30 min), large Stokes shift (120 nm), and green emission (550 nm).

Products