Aspergillolide, a new 12-membered macrolide from sea cucumber-derived fungus Aspergillus sp. S-3-75

  • Nat Prod Res. 2020 Apr;34(8):1131-1137. doi: 10.1080/14786419.2018.1552699.
Jun-Jie Tan  1  2 ,  Xiao-Yu Liu  3 ,  Yang Yang  1 ,  Feng-Hua Li  1 ,  Chang-Heng Tan  2 ,  Yi-Ming Li  1
Affiliations
  • 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • 2. Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China.
  • 3. Department of Biochemistry and Molecular Biology, Naval Military University, Shanghai, China.
PMID: 30663348 DOI: 10.1080/14786419.2018.1552699
Abstract

A new 12-membered Macrolide, aspergillolide (1), along with nine known compounds (2-10), were isolated from the fungus Aspergillus sp. S-3-75 associated with the sea cucumber Holothuria nobilis Selenka. The structure and absolute stereochemistry of 1 were elucidated on the basis of extensive spectroscopic methods and single crystal X-ray diffraction analysis.

Keywords
Aspergillus; Holothuria nobilis; aspergillolide; macrolide.
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