Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities

  • Molecules. 2019 Jan 30;24(3):489. doi: 10.3390/molecules24030489.
Hong Xu Li  1 ,  Seo Young Yang  2 ,  Young Ho Kim  3 ,  Wei Li  4
Affiliations
  • 1. College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. [email protected].
  • 2. College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. [email protected].
  • 3. College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. [email protected].
  • 4. Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea. [email protected].
PMID: 30704047 DOI: 10.3390/molecules24030489
Abstract

Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble Epoxide Hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC50 value of 58.5 µM.

Keywords
Piper crocatum; Piperaceae; phenolic; soluble epoxide hydrolase activity.
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