Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax

  • Exp Biol Med (Maywood). 2019 May;244(8):621-629. doi: 10.1177/1535370219833624.
Kelsey Jensen  1 ,  David Jasen WuWong  1 ,  Sean Wong  1 ,  Mieko Matsuyama  1 ,  Shigemi Matsuyama  1
Affiliations
  • 1. Division of Hematology and Oncology, Department of Medicine, School of Medicine, Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA.
PMID: 30836793 DOI: 10.1177/1535370219833624
Abstract

Bax induces mitochondria-dependent programed cell death. While cytotoxic drugs activating Bax have been developed for Cancer treatment, clinically effective therapeutics suppressing Bax-induced cell death rescuing essential cells have not been developed. This mini-review will summarize previously reported Bax inhibitors including peptides, small compounds, and antibodies. We will discuss potential applications and the future direction of these Bax inhibitors.

Keywords
Apoptosis; Bax; Bax inhibitor; Ku70; cell death; cell-penetrating peptide; drug delivery.
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