Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from Penicillium raistrickii IMB17-034

  • J Nat Prod. 2019 May 24;82(5):1391-1395. doi: 10.1021/acs.jnatprod.9b00259.
Jiao Li  1 ,  Yuanyuan Hu  1 ,  Xiaomeng Hao  1 ,  Jiali Tan  1 ,  Fang Li  1 ,  Xinran Qiao  1 ,  Shuzhen Chen  1 ,  Chunling Xiao  1 ,  Minghua Chen  1 ,  Zonggen Peng  1 ,  Maoluo Gan  1
Affiliations
  • 1. Institute of Medicinal Biotechnology , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
PMID: 31013089 DOI: 10.1021/acs.jnatprod.9b00259
Abstract

Raistrickindole A (1), a new indole diketopiperazine alkaloid containing an unusual pyrazino[1',2':2,3][1,2]oxazino[6,5- b]indole tetraheterocyclic ring system, a new benzodiazepine derivative, raistrickin (2), and the known haenamindole (3) and sclerotigenin (4) were isolated from the marine-derived fungus Penicillium raistrickii IMB17-034. Their structures were elucidated by extensive spectroscopic analyses and TDDFT calculations of the NMR and ECD data. Compounds 1 and 2 showed inhibitory activities against the hepatitis C virus.