New phenylpropanoid allopyranosides from the rhizomes of Cimicifuga dahurica

  • Bioorg Med Chem Lett. 2019 Jul 15;29(14):1774-1778. doi: 10.1016/j.bmcl.2019.05.011.
Qing Lu  1 ,  Hai-Bo Li  2 ,  Qian-Qian Pang  1 ,  Wei-Yang Zhang  3 ,  Zhen-Zhen Su  2 ,  Da-Bo Pan  1 ,  Xin-Sheng Yao  4 ,  Yang Yu  5
Affiliations
  • 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China.
  • 2. Kanion Pharmaceutical Co. Ltd., State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China.
  • 3. Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • 4. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address: [email protected].
  • 5. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address: [email protected].
PMID: 31126853 DOI: 10.1016/j.bmcl.2019.05.011
Abstract

Five new phenylpropanoid allopyranosides (1-5), along with five known compounds (6-10) were isolated from the rhizomes of Cimicifuga dahurica. Their structures were established by means of spectroscopic analyses and chemical methods, as well as comparison with literatures. The anti-inflammatory activities of all isolates were evaluated. Compounds 6, 9 and 10 exhibited inhibitory effects on PGE2 production in LPS stimulated RAW 264.7 macrophages with IC50 values of 19.72, 6.33 and 39.90 µM, respectively.

Keywords
Anti-inflammatory; Cimicifuga dahurica; PGE(2); Phenylpropanoid glycosides.