Polyketides from Alternaria alternata MT-47, an endophytic fungus isolated from Huperzia serrata

  • Fitoterapia. 2019 Sep:137:104282. doi: 10.1016/j.fitote.2019.104282.
Hongyun Yang  1 ,  Bowen Qi  1 ,  Ning Ding  1 ,  Fangfang Jiang  1 ,  Fangfang Jia  1 ,  Yuan Luo  1 ,  Xiping Xu  1 ,  Lili Wang  1 ,  Zhixiang Zhu  1 ,  Xiao Liu  1 ,  Pengfei Tu  1 ,  Shepo Shi  2
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
  • 2. Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; Beijing Key Lab for Quality Evaluation of Chinese Meteria Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address: [email protected].
PMID: 31381956 DOI: 10.1016/j.fitote.2019.104282
Abstract

Four new polyketides, alternatains A-D (1-4), along with 17 known compounds (5-21) were obtained from the solid substrate fermentation cultures of Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Their structures were elucidated by extensive spectroscopic and spectrometric techniques (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) method. Compounds 4, 6, 15, and 21 exhibited inhibitory activities on ATP release of thrombin-activated platelets with IC50 values in the range of 18.2-68.8 μM.

Keywords
Alternaria alternata; Anti-platelet activity; Endophytic fungus; Huperzia serrata; Polyketides.
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