Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon

  • J Nat Prod. 2019 Oct 25;82(10):2828-2834. doi: 10.1021/acs.jnatprod.9b00522.
Yuen P Tan ,  Yongbo Xue  1 ,  Andrei I Savchenko ,  Sevan D Houston ,  Naphak Modhiran ,  Christopher L D McMillan ,  Glen M Boyle  2 ,  Paul V Bernhardt ,  Paul R Young ,  Daniel Watterson ,  Craig M Williams
Affiliations
  • 1. School of Pharmaceutical Sciences (Shenzhen) , Sun Yat-Sen University , Guangzhou , 510275 , People's Republic of China.
  • 2. QIMR Berghofer Medical Research Institute , PO Royal Brisbane Hospital, Brisbane , 4029 , Queensland , Australia.
PMID: 31553187 DOI: 10.1021/acs.jnatprod.9b00522
Abstract

The highly oxygenated pimarane Diterpenoids basimarols A, B, and C (3-5) were isolated from the plant species Basilicum polystachyon, which was collected within the Australian arid zone. Structure elucidation was performed using a suite of spectroscopic techniques, including X-ray crystallography. Anticancer and anti-DENV activity of 3-5 was explored, but only limited activity was observed. More extensive Antiviral evaluation of stachyonic acid A (1), which was also isolated from B. polystachyon, revealed broad spectrum Antiviral activity against West Nile virus (Kunjin strain, WNVKun) and human influenza viruses H1N1 and H3N2.