Cytotoxic Activity of Cunila angustifolia Essential Oil

  • Chem Biodivers. 2020 Feb;17(2):e1900656. doi: 10.1002/cbdv.201900656.
Matheus H O de Sousa  1 ,  Jessica M S Morgan  1 ,  Karina Cesca  2 ,  Adriana Flach  3 ,  Neusa F de Moura  1
Affiliations
  • 1. Natural Products Research Group, Federal University of Rio Grande, St. Cel. Francisco Borges de Lima, n. 3005, Bom Princípio, Santo Antônio da Patrulha, 95500-000, RS, Brazil.
  • 2. Federal University of Santa Catarina, St. Eng. Agronômico Andrei Cristian Ferreira, Trindade, Florianópolis, 88040-900, SC, Brazil.
  • 3. Federal University of Roraima, Av. Cap. Ene. Garcês, n. 2413, Aeroporto, Rio Branco, 69310-000, RR, Brazil.
PMID: 31910318 DOI: 10.1002/cbdv.201900656
Abstract

The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC-FID and GC-MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and Other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human Cancer cell lines of the lung (A549), breast (MCF-7) and skin melanoma (SK-Mel-28). The assay showed the highest selectivity, to MCF-7 cell lines, with IC50 equal to 34.0 μg mL-1 , low selectivity for SK-Mel-28 cell lines, with IC50 equal to 279.9 μg mL-1 , and no mortality to A549 cell lines.

Keywords
Cunila angustifolia; essential oil; menthol; pulegone; terpene.
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