R-Hexitronic acid, a new tetronic acid derivative isolated from a soil fungus FG9RK

  • Nat Prod Res. 2021 Nov;35(21):3578-3583. doi: 10.1080/14786419.2020.1715400.
Kenneth G Ngwoke  1  2 ,  Dina H El-Kashef  1  3 ,  Georgios Daletos  1 ,  Elena Ancheeva  1 ,  Zhen Liu  1 ,  Festus B C Okoye  2 ,  Charles O Esimone  4 ,  Peter Proksch  1
Affiliations
  • 1. Institute of Pharmaceutical Biology, Heinrich Heine University, Duesseldorf, Germany.
  • 2. Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
  • 3. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • 4. Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
PMID: 31971016 DOI: 10.1080/14786419.2020.1715400
Abstract

A new tetronic acid derivative (1) together with terrestric acid (2), a known metabolite of Penicillium species, was isolated from the soil fungus, FG9RK following fermentation on solid rice medium. The structure of 1 was elucidated by one- and two-dimensional NMR and MS measurements. The absolute configuration of the oxygenated carbon in the side chain of 1 was identified as S by converting the compound into its Mosher ester whereas the absolute configuration of the lactone ring was deduced based on biogenetic considerations and comparison with 2.

Keywords
Tetronic acid; fungal metabolite; furanone; soil fungi.
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