Erythromycin A 11,12-methylene acetal
- J Antibiot (Tokyo). 1988 Nov;41(11):1644-8. doi: 10.7164/antibiotics.41.1644.
Affiliations
- 1. Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
PMID: 3198496
DOI: 10.7164/antibiotics.41.1644
Abstract
Erythromycin A 11,12-methylene acetal (5) and the corresponding 9-methoxime, 9-dihydro, and 8-hydroxy derivatives have been prepared and their Antibacterial activities compared with those of erythromycin A and its 11,12-cyclic carbonate. The simple methylene acetal 5 showed excellent activity against Gram-positive organisms in vitro.
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