Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities

  • Chem Pharm Bull (Tokyo). 2020;68(7):671-674. doi: 10.1248/cpb.c20-00080.
Sirada Boonyaketgoson  1  2 ,  Yongle Du  2 ,  Ana L Valenciano Murillo  3 ,  Maria B Cassera  3 ,  David G I Kingston  2 ,  Kongkiat Trisuwan  1  4
Affiliations
  • 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University.
  • 2. Department of Chemistry, Virginia Tech.
  • 3. Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia.
  • 4. Research Center on Chemistry for Development of Health Promoting Products from Northern Resources, Chiang Mai University.
PMID: 32612002 DOI: 10.1248/cpb.c20-00080
Abstract

Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM.

Keywords
Artocarpus lakoocha; antimycobacterial activity; antiplasmodial activity; cytotoxic activity.
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