Dimeric Tetrahydroanthracene Regioisomers and Their Monomeric Precursor Produced by Streptomyces fumigatiscleroticus HDN10255

  • J Nat Prod. 2020 Sep 25;83(9):2797-2802. doi: 10.1021/acs.jnatprod.0c00805.
Junxiao Wang  1 ,  Haotian Wang  1  2 ,  Chunxiao Sun  1 ,  Fenge Li  1 ,  Yingqiang Wu  1 ,  Guojian Zhang  1  3 ,  Qianqun Gu  1 ,  Tianjiao Zhu  1 ,  Dehai Li  1  3 ,  Qian Che  1
Affiliations
  • 1. School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • 2. Faculty of Pharmacy, Bengbu Medical College, Bengbu 233030, People's Republic of China.
  • 3. Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, People's Republic of China.
PMID: 32880456 DOI: 10.1021/acs.jnatprod.0c00805
Abstract

Four new tetrahydroanthracene derivatives (1, 3-5) and a known Antibiotic, A-39183A (2), were discovered from the marine-sponge-derived actinomycete Streptomyces fumigatiscleroticus HDN10255. Their structures including absolute configurations were elucidated based upon MS and NMR spectroscopic data, ECD calculations, and biogenetic considerations. Compounds 2 and 4 showed considerable cytotoxicity with the best IC50 value of 1.8 μM against HeLa cells.

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