Iridoids from Valeriana jatamansi with anti-inflammatory and antiproliferative properties

  • Phytochemistry. 2021 Apr;184:112681. doi: 10.1016/j.phytochem.2021.112681.
Huan Liu  1 ,  Dan Liu  1 ,  Ming-Yan Jiang  1 ,  Xu-Dong Zhao  2 ,  Rong-Tao Li  3 ,  Hong-Mei Li  4
Affiliations
  • 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China.
  • 2. Laboratory of Animal Tumor Models, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China.
  • 3. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: [email protected].
  • 4. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: [email protected].
PMID: 33548771 DOI: 10.1016/j.phytochem.2021.112681
Abstract

Seven undescribed (valejatadoids A-G) and 26 known Iridoids were obtained from the roots and rhizomes of Valeriana jatamansi. Their structures were determined based on extensive spectroscopic data, especially 1D and 2D NMR, along with HRESIMS. Valejatadoid B is a monoene-type iridoid with a unique double bond between C-4 and C-5. Valejatadoids D-G, jatamanin U, jatamanin O, jatamanvaltrate E, valeriotetrate C, IVHD-valtrate, 10-isovaleroxy-valtrathydrin, jatamanvaltrate Q, valeriandoid F, jatamanvaltrate K, jatamanvaltrate W and isovaltrate were more potent than the positive control when evaluated for inhibition of NO production. Among them, valeriandoid F and jatamanvaltrate K exhibited the most significant inhibitory effects with IC50 values of 0.88 and 0.62 μM, respectively. In addition, valeriandoid F selectively inhibited the proliferation of human glioma stem cell lines, GSC-3# and GSC-18#, with IC50 values of 7.16 and 5.75 μM, respectively.

Keywords
Anti-inflammatory and antiproliferative activities; Caprifoliaceae; Iridoids; Valeriana jatamansi Jones ex Roxb..
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