Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

  • Biology (Basel). 2021 Feb 4;10(2):116. doi: 10.3390/biology10020116.
Francisco Perez-Dominguez  1 ,  Diego Carrillo-Beltrán  1 ,  Rancés Blanco  1 ,  Juan P Muñoz  2 ,  Grettell León-Cruz  3 ,  Alejandro H Corvalan  4 ,  Ulises Urzúa  5 ,  Gloria M Calaf  2  6 ,  Francisco Aguayo  7
Affiliations
  • 1. Laboratorio Oncovirología, Programa de Virología, Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago 8380000, Chile.
  • 2. Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.
  • 3. Centro Universitario del Sur, Laboratorio de Ciencias Fisiológicas, Departamento de Ciencias Básicas para la Salud, Universidad de Guadalajara, Guadalajara 44100, Mexico.
  • 4. Advanced Center for Chronic Diseases (ACCDIS), Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.
  • 5. Departamento de Oncología Básico Clínica (DOBC), Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
  • 6. Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA.
  • 7. Instituto de Alta Investigación, Sede Esmeralda, Universidad de Tarapacá, Iquique 1101783, Chile.
PMID: 33557375 DOI: 10.3390/biology10020116
Abstract

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in Cancer development remains a novel area of study. This review presents accumulating evidence on the contribution of Pirin in epithelial cancers, involved signaling pathways, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and Cancer development.

Keywords
cancer; epithelial; pirin.