Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines

  • Top Curr Chem (Cham). 2021 Feb 24;379(2):13. doi: 10.1007/s41061-020-00314-6.
Mallu Lavanya  1  2 ,  Chong Lin  3 ,  Jincheng Mao  4 ,  Dhakshanamurthy Thirumalai  5 ,  Sreenath Reddy Aabaka  1 ,  Xiaojiang Yang  1 ,  Jinhua Mao  1 ,  Zhiyu Huang  2 ,  Jinzhou Zhao  1
Affiliations
  • 1. State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, 610500, Xindu, People's Republic of China.
  • 2. School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, 610500, People's Republic of China.
  • 3. State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, 610500, Xindu, People's Republic of China. [email protected].
  • 4. State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, 610500, Xindu, People's Republic of China. [email protected].
  • 5. Department of Chemistry, Thiruvalluvar University, Vellore, 632 115, Tamil Nadu, India. [email protected].
PMID: 33624162 DOI: 10.1007/s41061-020-00314-6
Abstract

The burgeoning interest in synthesis and biological applications of 1,6-naphthyridines reflects the importance of 1,6-naphthyridines in the synthetic as well as medicinal chemistry fields. Specially, 1,6-naphthyridines are pharmacologically active, with variety of applications such as Anticancer, anti-human immunodeficiency virus (HIV), anti-microbial, analgesic, anti-inflammatory and anti-oxidant activities. Although collective recent synthetic developments have paved a path to a wide range of functionalized 1,6-naphthyridines, a complete correlation of synthesis with biological activity remains elusive. The current review focuses on recent synthetic developments from the last decade and a thorough study of the Anticancer activity of 1,6-naphthyridines on different Cancer cell lines. Anticancer activity has been correlated to 1,6-naphthyridines using the literature on the structure-activity relationship (SAR) along with molecular modeling studies. Exceptionally, at the end of this review, the utility of 1,6-naphthyridines displaying activities Other than Anticancer has also been included as a glimmering extension.

Keywords
1,6-Naphthyridines; Anticancer activity; Cancer cell lines; Mechanism of action; Molecular modeling studies; Structural–activity relationship; Synthetic approaches.
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