Isolation and identification of belamcandaoids A-N from Belamcanda chinensis seeds and their inhibition on extracellular matrix in TGF-β1 induced kidney proximal tubular cells

  • Bioorg Chem. 2021 Sep:114:105067. doi: 10.1016/j.bioorg.2021.105067.
Ying-Ying Song  1 ,  Jian-Bing Jiang  2 ,  Yong-Ming Yan  2 ,  Yong-Xian Cheng  3
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
  • 2. Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China.
  • 3. Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China; Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, PR China. Electronic address: [email protected].
PMID: 34120020 DOI: 10.1016/j.bioorg.2021.105067
Abstract

Belamcandaoids A-N (1-14), fourteen new triterpenoids were isolated from the seeds of Belamcanda chinensis. Their structures including absolute configurations were assigned by using spectroscopic, computational, and crystallographic methods. All the compounds except 1 and 2 are 3,4-seco-triterpenoids belonging to fernane type. Biological evaluation results indicated that 3 and 13 could reduce fibronectin and Collagen I expression respectively in TGF-β1 induced kidney proximal tubular cells.

Keywords
Belamcanda chinensis; Kidney proximal tubular cells; TGF-β1; Triterpenoids.
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