Two new chromones and a new coumarin from the fruit of Cnidium monnieri (L.) Cusson

  • Nat Prod Res. 2023 Jan;37(1):47-55. doi: 10.1080/14786419.2021.1948042.
Hui-Chi Huang  1  2 ,  Chun-Hsiang Lin  3 ,  Ching-Chuan Kuo  4 ,  Ming-Der Wu  5 ,  Ming-Jen Cheng  5 ,  Jih-Jung Chen  6 ,  Che-Yi Chao  7 ,  Guan-Jhong Huang  1 ,  Yueh-Hsiung Kuo  1  8  9
Affiliations
  • 1. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
  • 2. Master Program for Food and Drug Safety, China Medical University, Taichung, Taiwan.
  • 3. Department of Chemistry, National Taiwan University, Taipei, Taiwan.
  • 4. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
  • 5. Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
  • 6. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan.
  • 7. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
  • 8. Department of Biotechnology, Asia University, Taichung, Taiwan.
  • 9. Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
PMID: 34519597 DOI: 10.1080/14786419.2021.1948042
Abstract

Two new chromones named cnidimol G (1) and cnidimol H (2), one new coumarin, 7-methoxy-8-(3-methoxy-3-methyl-2-oxobutyl)coumarin (3), and twenty known compounds were isolated from MeOH extract of the fruit of Cnidium monnieri (L.) Cusson. The structures of compounds were elucidated by extensive spectroscopic analyses including 1 D and 2 D NMR, HRESIMS, IR and UV. Anti-inflammatory activity of the selected isolated compounds were evaluated. Compounds 1 and 8 exhibited inhibitory activities against nitric oxide production.

Keywords
Cnidium monnieri (L.) Cusson; anti-inflammatory activity; chromones; coumarin.
Products